Delta Blues — Variant that overwhelmed India threatens the West

Delta Blues

variant that overwhelmed India threatens the West

July 29th 2021

Three states totaling one fourth of the US population made up 40% of new cases of COVID-19 last week. All were in the South, all were heavily Republican, and all had very low rates of vaccination against COVID. Even more dismaying, over 80% of new cases were the Delta variant.

There is more news about the Delta variant, and most of it is pretty bad. First, there’s the matter of the transmission rate. It has an R0 between 5 and 8, which means that an infected individual can be expected to infect between 5 and 8 susceptible individuals. For comparison, the Alpha variant had an R0 between 4 and 5. A report by the Washington Post tonight suggest the R0 estimate may be revised upward, which is catastrophically bad news.

When the R0 is four, this is how it can spread: If you infect an expected four people, and each in turn infects 4 more, that’s 20 people. Those sixteen new cases go on to infect 64 more. Those 64 infect 256 more. It’s exponential growth, and the numbers grow very rapidly.

But if the R0 is eight, then one person infects 8, they in turn infect 64, they in turn infect 512, and they infect 4,096. Same number of stages of growth, but one number is eight times as high. The gaps widens exponentially. The gap is 16 times as high in the next stage.

By way of comparison, the flu has a R0 between 1.3 and 1.6, depending on the strain. In a typical flu season, millions get the flu, thousands die, although vaccines are causing a drop in those numbers. (Because of social distancing, a happy side effect was that “flu season” last winter was the smallest in at least 100 years). The common cold has an R0 between 2 and 3, and yet nearly everyone gets at least one cold in a given year. Of course, there’s hundreds of strains of virus out there that cause the cold, and it’s just a part of our lives. But those R0 rates should scare any one capable of doing simple arithmetic.

Rubella, which is notoriously contagious, has an R0 of 6 and 7, making it essentially as infectious as the Delta variant. The mumps, which used to routinely wildfire through entire school districts, has an R0 of 10-12. So does chickenpox. The regular measles has an R0 of 12-18.

It gets worse: people who have received both shots, either Moderna or Pfizer, may only have an 8-10% chance of being infected with the Alpha variant and are considered fairly low risk to carry it on. With the Delta variant, the chance of infection is higher, although it is yet to be determined how much higher. The one bit of good news is that 90% of those with vaccines will have mild or non-existent symptoms. However, they “virus load” (i.e. become as contaminated) as non-vaccinated people, and can pass the disease along to nearly all unvaccinated and an unknown but sizable number of vaccinated people.

When I was a kid, measles, mumps and chickenpox were very nearly inevitable, and sometimes killed kids. I’m glad they are part of our past, along with diseases like polio and smallpox.

The elephant in the room is “long COVID”–a galaxy of aftereffects that range from annoying to debilitating. Respiratory issues, vascular problems, “brain fog”, fatigue and susceptibility to other diseases. It is known to show up in people who remained asymptomatic in the initial stages of the disease. We have no clear idea how or even if it manifests in people who have gotten their shots and become infected. It may take years before we really do know. But the threat is there.

So if you have your shots and you’re swanning around maskless, stop doing that right now. What for you might be nothing worse than a mild cold could mean potentially significant health issues for you in the future.

You will also be a deadly threat to anyone you encounter who hasn’t been vaccinated. If you infect 8 people and they infect 64 and they infect 512, the odds are you just killed a half dozen people, and hospitalized about 24 others.

So mask up and observe social distancing. Yes, we’re all sick to death of it, and furious at the fools who won’t take steps to defend themselves and everyone else, but unless we want America to be the first country to stupid itself to death, we need to keep taking these steps and hope our social recklessness doesn’t open the door to even bigger medical problems.

Mask up. Keep your distance, and if you haven’t yet, get your shots. Over 163 million have, and it’s clear they are safe and effective. And yes, Delta variant is effective in its own way, but it sure ain’t safe.

Stay safe, exercise better sense than a squirrel on the freeway, and we’ll get through this.

Joe’s first White House Speech — Reasonable Assurances and Sensible Warnings

Joe’s first White House Speech

Reasonable Assurances and Sensible Warnings

March 11th, 2021

Day fifty of the Biden presidency, and so far so good. Both politically and psychologically, today was a good point for Biden to stop and have a talk with the people. It came a few hours after he signed into law the biggest rebuilding act America had seen since FDR’s first 100 days. The American Rescue Act will, in the estimate of Goldman-Sachs, result in 8% annual growth over the next 12 months. That, too, is a rate of growth not seen since the 1930s. Best of all, it’s going to people and small businesses, what you could call “trickle up economics.” It will save thousands of small businesses, protect millions from hunger and homelessness. It is, as Biden once put it about the AMA, “a big fucking deal.”

In the glow from this massive legislative victory, Biden addressed the state of the country on the anniversary of the Covid pandemic.

After the past year where lies, braggadocio and delusions were all Americans got from the White House, Biden’s cautionary optimism was a gust of fresh air. Biden extolled the immense gains the vaccine program had made in the past 50 days, but didn’t try to pretend it was all his doing. (In a truly pathetic footnote, Trump put out a brief communiqué under a sort-of presidential seal, from The Office of Donald J. Trump, trying to take credit for the vaccine program.) The program has been pretty much miraculous, despite Trump. When Biden first took office, he spoke of 100 million vaccines in the first 100 days (the last day of April). That was considered a high goal, even before we learned that the outgoing administration had absolutely no plan in place for distribution or even procurement of the needed vaccines.

Now, not only are we well ahead of pace for that, but we may have vaccines available for the entire adult population by the end of May, some 500 million shots all told. The CDC is of the opinion that we’ll have herd immunity by the beginning of May, but Doctor Fauci, on the Rachel Maddow show tonight, cautioned that we are in a race against variants, and we may, even with full vaccinations, end up playing whack-a-mole (his term) with those variants, much the way we do with strains of flu and the common cold. It’s evolution, people.

Biden himself made the same cautionary note, and urged people to keep on social distancing and wearing masks for the time being, despite what the “Neanderthals” in the GOP think we should be doing. It’s not a popular request, but Biden has some courage. Things are a lot more hopeful, but we are not out of the woods. He’s right, Fauci’s right, and nearly every expert in the field is right. Tucker Carlson, Alex Jones and Donald Trump are all wrong, and for vicious, self-serving reasons.

Biden spoke movingly of the loss and deprivation hundreds of millions of people suffered over this past year—well over half a million dead (“more than World War I, World War II, and 9/11”), millions of families separated, millions of jobs lost. Even the most cynical of viewers had to admit that he SOUNDED sincere.

He knows, at long last, that there is a light at the end of the tunnel, and he just wants us not to derail ourselves by being reckless as we approach the light. It won’t stop the freedumb morons, but it might just keep enough sane people cautious enough that we might get by.

Fauci and Maddow were talking about monoclonal antibody treatments. Two studies showed respectively 87 and 89% efficacy if administered early in the course of the disease, numbers so convincing that they dropped the double blind nature of the studies on the ground that it was not moral to give half the subjects a placebo based on what is known.

This doesn’t mean that you can run out licking random seats in the New York subway knowing you just need to pop two in the mouth and you’ll be all better. The treatments are by infusion only, and still very expensive. And if you get to the point where the symptoms are life-threatening, then you’re far enough along that the treatment will be of little or any help. Fauci is hoping for a treatment that involves simple injections, or even just pills, but that’s an unknown amount of time in the future. It’s not here, and may not be here for years, but there is a cure.

Not mentioned was the spectre of “long COVID”. Roughly a third of people who become infected develop symptoms weeks or months later, even if they were completely asymptomatic to begin with. And yes, you can still be infected, even with the shots. You just are very unlikely to develop symptoms, and in the beginning, they will be mild. Nobody knows how that will affect development of “long COVID.”

Futher, variants are appearing, and while the evolutionary trend is for such variants to become both more contagious and milder (the weeding-out process of evolution means viruses that successfully inhabit live hosts will outnumber the ones that kill their hosts) that is just a trend. The mutations are individually random, and a variety of Covid could show up that is as lethal as Ebola and as communicable as measles. Worst case scenario, to be sure, but within the realm of possibility. And if we are reckless and go on acting as a culture medium for this virus, the higher the chances that something even nastier will crop up. And the more variations, the more types of vaccines are needed unless and until we can come up with an umbrella shot that can block all Covids. Note: we haven’t been able to develop a shot like that for influenza, and with the common cold, it’s pointless to even try.

Because of this, Biden’s speech was perfect for the occasion. He didn’t tell us what we wanted to hear. He told us what we needed to hear, and for most of us, that’s going to help us a lot through the coming year.

 

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